In-Vivo Pharmacokinetics Study

Pharmacokinetic response profiling

The aim of this study is to determine the impact of various animal and dosing characteristics on the absorption of a therapeutic compound into the bloodstream. Analytical data on blood concentration is collected into Riffyn alongside study data characterizing the animal physiology and dosing parameters. Riffyn is used to automatically integrate the data into a statistical data frame and then feed the data frame to JMP for multivariate analysis. Two factors are determined to have a statistically significant impact on adsorption, one is shown to be irrelevant.

The data from the study can be easily analyzed to identify key trends. In this study, the speed of absorption between each of the doses, animal, and administration pathway.

An analysis of the data for this study shows that gender has no impact on absorption but the route and animal type (diabetic vs not diabetic) have significant impact.

Process and experiment design were created, and data were captured and prepared with Riffyn. Plots were created with JMP® Software. Copyright 2018, SAS Institute Inc., Cary, NC, USA. All Rights Reserved. Reproduced with permission of SAS Institute Inc., Cary, NC.

"This type of statistical analysis is very easy with Riffyn because all of the underlying data across the entire experiment is prepared and exported in a statistical data table that can be opened inside your preferred analysis program."


Highlighted in the Video

Study design

Data collection & joining

Statistical analysis with JMP

in-vivoDouglas Williams