Case Study

Formulations case study

Using Riffyn Nexus, a global oral solid dose manufacturer was able to connect data across process steps in a matter of minutes instead of the 16 hours of error-prone effort it previously required. This allowed on-demand investigations of cause-and-effect across process steps and materials that delivered significant new process insights.


Learn how a global oral solid dose manufacturer has been able to:

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    Save 16 hours of error-prone effort per experiment

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    Achieve on-demand investigations of cause-and-effect across process steps and materials to deliver significant new insights

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    Equip their staff to capture large aggregate data sets and drive decisions as independent groups without outside technical expertise

Formulations CS left

Manufacturing oral solid doses requires several protocols and produces loads of data that must be assessed in context to make the right decisions. The combination of operations you might do to get a tablet suitable for use is numerous -- and making the right decisions is critical.

Using Riffyn Nexus, a global oral solid dose manufacturer was able to connect data across process steps in a matter of minutes instead of the 16 hours of error-prone effort it previously required. This allowed on-demand investigations of cause-and-effect across process steps and materials that delivered significant new process insights. Here’s how they did it -- and how you can use the same digital transformation approach to solve your own manufacturing bottlenecks.

Our customer’s goal was to equip their staff to capture large aggregate data sets and drive decisions as independent groups -- no outside technical expertise necessary. A few critical hurdles were in the way. Several laboratory instruments fed data into a number of different folders, each data file had its own custom script -- or, even worse, required manual processing to collate into a file that could be reported on -- and yet other data files resided only in ELNs and were not interpretable by tools for data analytics.

Riffyn broke down each unit operation along the life cycle of pill manufacture, from blending to finished product, into modules that could easily be mixed and matched and brought together for analysis. Using this modular approach, the Riffyn Science team built 15 processes comprising dozens of experiments for multiple oral solid dose formulation projects. And, once our customer became familiar with Riffyn Nexus, they built an additional 9 processes with support from the Riffyn team.

In only three months, our customer had gained an interconnected system of processes that eliminated the need for Excel templates, ELNs, and secondary databases -- saving time and reducing human error. They also leveraged Riffyn’s ontology and documentation and execution framework to ensure consistent and reproducible data capture -- even across teams -- and they developed data parsing frameworks through a combination of Riffyn and other external tools to automatically extract and contextualize data. Using Riffyn to document cross-team work enabled ad-hoc investigations into connections across materials by joining data and contextualizing it in a matter of minutes.

Given the success achieved during this PoC, our customer has moved to implement Riffyn as a critical component for a number of manufacturing processes.


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